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November 14, 2006; 103 (46)

Cover illustration

Cover image expansion

Cover image: The FeMo cofactor (spheres), which is the active site of substrate reduction in the Mo-nitrogenase (comprising Fe protein and MoFe protein), is located within the α-subunit of MoFe protein (tubes). The final steps of FeMoco biosynthesis involve the insertion of molybdenum and homocitrate into the NifEN-bound FeMoco precursor by Fe protein and the transfer of the cluster to its destined location in MoFe protein upon protein-protein interaction. See the two articles by Hu et al. on pages 17119–17124 and 17125–17130. Image courtesy of Benedikt Schmid (Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany).

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