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April 21, 2009; 106 (16)

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Cover image: Schematic of a large-scale network perturbation of amino acid biosynthesis. Systems biology faces the challenge of integrating metabolic measurements across the functional levels of the cell. A new approach correlates 2 functional levels—MmRNA and metabolic flux—Mby combining information from interaction network models and flux determination models. See the article by Joel F. Moxley et al. on pages 6477–6482. The introduction to the Complex Systems: From Chemistry to Systems Biology Special Feature is on pages 6433–6434. Image courtesy of Gregory Stephanopoulos.

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