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August 26, 2014; 111 (34)

Cover image

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Cover image: Pictured are core elements of vaccination: viruses, bacteria, and protein structures surrounding a cladogram of B-cell immunoglobulin protein sequences. Rino Rappuoli introduces a series of articles that describe the history of vaccines, and how vaccines have eliminated many infectious diseases, increased life expectancies, and have the potential to address the medical needs of modern society if their development is prioritized. See the introduction by Rappuoli on page 12282, a part of the Vaccines PNAS 100th Anniversary Special Feature. Image courtesy of Giorgio Corsi (Novartis Vaccines, Siena, Italy).

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