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Cross-scale effects of neural interactions during human neocortical seizure activity

Supporting Information

  • Download Supporting Information (PDF)
  • Download Movie_S01 (MOV) - Seizure onset recorded from the MEA in patient 2, with the multiunit activity showing the ictal wavefront (Left) and 2- to 50-Hz LFP amplitude (Right); 5 s of the recording are shown beginning 0.5 s before onset. The trace at the top shows 2- to 50-Hz activity from a representative microelectrode. This trace resembles the nearby ECoG recording. Reprinted with permission from ref. 2.
  • Download Movie_S02 (MOV) - Movie showing the associated synaptic activity (uE and uI) when γ = 1/8 and input (b) is increased and then decreased again. The black dot denotes the trajectory observed in our simulated LFP shown in Fig. 6, Lower. The blue (excitatory) and red (inhibitory) lines correspond to the “nullclines” or the first and second derivatives when the synaptic activities of the excitatory and inhibitory populations are both zero. Intersections of the two curves are, therefore, equilibria of the system.
  • Download Movie_S03 (MOV) - Movie showing the associated synaptic activity when γ = 1/2 and input (b) is increased and then decreased again. Details are the same as in Movie S2.
  • Download Movie_S04 (MOV) - Movie showing the associated synaptic activity when γ = 3/4 and input (b) is increased and then decreased again. Details are the same as in Movie S2.

Online Impact

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