• Submit Earth, Atmospheric, and Planetary Sciences Papers
  • Science Sessions: The PNAS Podcast Program

Better support for a small effective population size of Neandertals and a long shared history of Neandertals and Denisovans

  1. Kay Prüfera,1
  1. aDepartment of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany

Rogers et al. (1) compare the sharing of derived alleles among the genomes of Africans, non-Africans, a Neandertal, and a Denisovan to infer the demographic history of archaic humans. They estimate that the effective population size (Ne) of Neandertals was ~15,000 individuals and that Neandertals and Denisovans separated from each other shortly after their ancestor separated from modern humans (~300 generations). These estimates are at odds with previous results (2) that suggested a smaller Ne for Neandertals [ranging from 1,000–5,000 individuals according to pairwise sequentially Markovian coalescent (PSMC) estimates of Ne over time] and a longer common branch for the Neandertal–Denisovan ancestor (5,000–10,000 generations). We note that the difference in assumed mutation rate between the two publications cannot account for the differences …

?1To whom correspondence should be addressed. Email: pruefer{at}eva.mpg.de.

Online Impact

  • 864971864 2018-01-22
  • 258841863 2018-01-22
  • 957295862 2018-01-22
  • 553518861 2018-01-22
  • 983792860 2018-01-22
  • 539694859 2018-01-22
  • 956115858 2018-01-22
  • 730379857 2018-01-22
  • 346624856 2018-01-22
  • 201609855 2018-01-22
  • 72549854 2018-01-21
  • 795928853 2018-01-21
  • 752345852 2018-01-21
  • 566508851 2018-01-21
  • 615722850 2018-01-21
  • 689612849 2018-01-21
  • 846903848 2018-01-21
  • 674896847 2018-01-21
  • 11197846 2018-01-21
  • 986896845 2018-01-21