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Structures of the type I DNA restriction enzymes

  1. David T. F. Drydena,1
  1. aDepartment of Biosciences, Durham University, Durham DH1 3LE, United Kingdom

The article by Liu et al. (1) on the structure of type I DNA restriction and modification enzymes purports to significantly advance our understanding of these enzymes and proposes a model for their operation. While the partial structure of one of these enzymes is interesting and defines the interface between some of the subunits, the article contains many misinterpretations of the literature.

In 1968, these enzymes were the first restriction enzymes to be purified (2). It was soon apparent that they contained three subunits; R, M, and S for restriction, modification, and sequence specificity, respectively, in the complex R2M2S1. A M2S1 complex could act …

?1Email: david.t.dryden{at}durham.ac.uk.

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